Complex genetics and microglia function in Alzheimer’s disease
About the labs
The Sleegers lab (Complex Genetics of Alzheimer’s Disease) and the Mancuso lab (Microglia and Inflammation in Neurological Disorders, MIND) at the VIB-UAntwerp Center for Molecular Neurology, Belgium, are seeking a highly motivated PhD student to work on a project on genetic and human microglia function in Alzheimer’s disease.
About the project
Microglia and neuroinflammation play a central role in the pathogenesis of Alzheimer’s disease and other neurodegenerative disorders. Whereas human genetics highlight microglia as main player, the actual mechanisms by which risk variants translate into aberrant microglia function in humans remain poorly understood. This project will start from a deep genomic investigation of Alzheimer risk loci to prioritize variants of interest, and use mouse models, multi-omics approaches, iPSC, CRISPR and cutting-edge humanized mouse systems to unravel how these variants affect microglia biology and contribute to the initiation and perpetuation of Alzheimer’s disease.
This is a project at the interface of two labs: the Mancuso lab, working on human and mouse microglia biology in brain disorders, and the Sleegers lab working on complex Alzheimer’s disease genetics. In this project, you will make use of innovative genetic and transcriptomic approaches, genome engineering, CRISPR and viral vector technology, iPSC and humanized mouse technology to unravel the link between genetic risk and microglia function in Alzheimer’s disease. The successful applicant will work in both labs.
We are seeking a highly motivated, enthusiastic, critical and creative individual to join our teams. The candidate should have a strong interest in neurobiology and wet lab or dry lab experience would be an advantage.
The position is open for candidates that have:
Desirable but not required:
Want to apply?
The University of Antwerp received the European Commission’s HR Excellence in Research Award for its HR policy. We are a sustainable, family-friendly organization which invests in its employees’ growth. We encourage diversity and attach great importance to an inclusive working environment and equal opportunities, regardless of gender identity, disability, race, ethnicity, religion or belief, sexual orientation or age. We encourage people from diverse backgrounds and with diverse characteristics to apply.Continue reading
|Title||PhD Complex genetics and microglia function in Alzheimer’s disease|
|Employer||University of Antwerp|
|Job location||Prinsstraat 13, 2000 Antwerpen|
|Published||April 20, 2021|
|Application deadline||May 6, 2021|
|Job types||PhD  |
|Fields||Neurology,   Neuroscience,   Bioinformatics,   Molecular Biology,   Genetics,   Cell Biology,   Developmental Biology,   Molecular Medicine  |