To strengthen our excellent research team, which is focused on the development and research of innovative approaches for the treatment of childhood cancer, we are looking for a PhD student (m/f/d) working on tumor immunoediting to work on tumor immunoediting. In this responsible role, you will have the unique opportunity to be part of a multidisciplinary competence center for pediatric oncology and to have a direct influence on the development of new cancer therapies.
Our group (https://www.ccri.at/eva-koenig-group/) studies the role of natural killer cells in tumor immunoediting and aims to identify the molecular mechanisms of tumor immune evasion in order to find novel therapeutic targets against leukemia with sustained success. We use DNA barcoding technologies, multiomics approaches (single-cell and bulk RNA-seq, ATAC-seq), genome editing (CRISPR/Cas9 gene knockout in cell lines, siRNA knock-down in primary immune cells), mouse models and a diverse array of in vitro functional studies (including multi-color flow cytometry). The project is funded by a FWF stand-alone grant and aims to find novel therapeutic targets to increase the immunogenicity of tumor cells and/or to improve NK cell functionality.
The St. Anna Children’s Cancer Research Institute (CCRI), located in the center of Vienna, the world’s most livable city and one of Europe’s most important places for biomedical research and life sciences, is an international and multidisciplinary competence center striving to improve treatment of children and adolescents with cancer by connecting translational and clinical research with open-minded exploration of basic disease mechanisms. Through close cooperation between clinic and research, the CCRI provides an ideal environment for cutting-edge research and its translation into clinical practice. To achieve our ultimate goal of advancing the well-being of patients, the CCRI constantly pushes scientific boundaries and strongly promotes close collaboration and exchange with external institutions like the Medical University of Vienna, CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, the Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA) and the Institute of Molecular Pathology (IMP).
The CCRI is an equal opportunity employer. We value diversity and are committed to providing a work environment of mutual respect to everyone without regard to ethnicity, religion, national origin, age, gender identity or expression, disability, or any other characteristic protected by applicable laws, regulations and ordinances.
We are looking forward to your application! Applications should at least contain your Curriculum Vitae, a cover letter, list of publications (please mark / explain your three top contributions), and the contact details of three references.Continue reading
|Title||PhD student (m/f/d) working on tumor immunoediting|
|Employer||St. Anna Children's Cancer Research Institute (CCRI)|
|Job location||Zimmermannplatz 10, 1090 Vienna|
|Published||June 15, 2021|
|Job types||PhD  |
|Fields||Biotechnology,   Cancer Research,   Oncology,   Molecular Biology,   Microbiology,   Immunology,   Genetics,   Cell Biology  |